Abstract：Domestic waste treatment is one of the most prominent weaknesses of the living environment in agro-pastoral areas of the Qinghai-Tibet Plateau. Clarifying the spatial variation and determinants of the level of domestic waste treatment in agro-pastoral areas provides the scientific foundation for comprehensively remediating the living environment in agro-pastoral areas and averting eco-environment risks in the Qinghai-Tibet Plateau. Taking 4315 administrative villages in Qinghai Province as an example， this paper analyzed the coverage rates of centralized domestic waste treatment and the proportion of population served in agro-pastoral areas at multiple scales. In addition， the determinants of the level of domestic waste treatment in agro-pastoral areas were quantified by using the logistic regression model for estimating the overall and zonal effects. The results show that： ①The coverage rate of centralized domestic waste treatment in agro-pastoral areas of Qinghai Province was inferior to the national and western region averages， showing a gradient descending pattern from Hehuang Valley agricultural area in eastern Qinghai to the Qaidam Basin and pastoral areas around Qinghai Lake and then to the highland alpine pastoralism in southern Qinghai； ②Multiple factors such as altitude， topography and transfer distance were strongly related to the level of domestic waste treatment in agro-pastoral areas. High altitude， mountainous terrain， and long-distance transfer were significant contributory factors to the deficiency of centralized domestic waste treatment in agro-pastoral areas； ③Multi-ethnic-populated pastoral areas with comparatively lagging economies and low resident populations were still vulnerable in terms of domestic waste treatment. Furthermore， the support of poverty alleviation policies and the increase in education level of managers had a positive impact on improving the level of domestic waste treatment. The main policy implications are as follows： Three models of treatment are applicable in the Qinghai-Tibet Plateau， which include a model of urban-rural integration treatment （domestic waste is originally collected in the village and then transferred to the town before it is finally disposed of in the county， model I）， centralized treatment in the town （domestic waste is also originally collected in the village but disposed of in the town， model II）， and decentralized treatment in pastoral areas （domestic waste is collected and disposed of directly in the village， model III） under the conditions of the cost of centralized treatment， the distribution of resident population and the characteristics of pollutants. Additionally， it is wise for the government to adopt methods such as purchasing services and establishing public service positions to motivate the government， agro-pastoralists， and enterprises to jointly participate in domestic waste treatment， so that comprehensively advance the level of domestic waste treatment and optimize the quality of the living environment in agro-pastoral areas.