Abstract：Fe2+/CaO2 Fenton-like system is easily limited by the slow iron ion cycle in practical applications. Herein， commercial WS2 as a co-catalyst of Fe2+/CaO2 to promote the Fe3+/Fe2+ cycle for efficient degradation of bisphenol A （BPA）. Under the optimal conditions， the degradation rate of BPA （10 mg?L-1） was 99.7% within 15 min in WS2/Fe2+/CaO2 system. Besides， the system could be suitable for various water bodies and degrade other refractory organic pollutants， which showed good application prospects. Radical quenching experiments and EPR analysis showed that hydroxyl radical （·OH）， superoxide radical （·O2-） and singlet oxygen （1O2） were the main reactive oxygen species for BPA degradation， and ·OH contribute most to the degradation of BPA. The exposed W4+ reductive sites on the surface of WS2 promoted the regeneration of Fe2+ and further improved the catalytic performance of Fenton-like system. WS2 exhibited good stability， and the degradation rate of BPA was still as high as 99% even after six repeated cycles. This study provides a new insight into calcium peroxide-based Fenton-like for the treatment of organic wastewater.