Abstract：With the pollution of heavy metal cadmium （Cd） becoming more and more serious， it is urgent to find effective treatment methods for soil Cd pollution. In this study， Koelreuteria Paniculata， a plant species with potential for Cd recovery， was studied by transcriptome analysis to investigate gene expression and metabolic pathways in shoots and roots of K. paniculata under different concentrations of Cd. Transcriptomic RNA-seq results showed that a total of 65171 Unigenes were obtained. The differentially expressed genes in roots were significantly more than in stems and leaves， and the down-regulated genes were more than up-regulated genes. The GO enrichment results showed that the intracellular ribonucleoprotein complex， ribonucleoprotein complex and macromolecular complex were the main enrichment parts of differentially expressed genes in K. paniculata roots under Cd stress. In the aboveground part， the differentially expressed genes were mainly concentrated in the intramembrane component and the membrane part. KEGG pathway enrichment analysis showed that ribosomes， phagocytes and tricarboxylic acid cycles were the main enrichment pathways in roots. Plant hormone signal transduction pathways were significantly enriched in leaves. Identification results of transcription factors showed that genes of ten transcription factor families were differentially expressed in response to Cd stress， including C2H2， MYB， WRKY and BZIP， which were significantly expressed. Transcriptome sequencing was used to analyze the response mechanism of K. paniculata to Cd stress. The results showed that K. paniculata expressed specific genes to achieve strong Cd resistance through the specific stress response to Cd stress. The results will provide a fundation for the further study of the molecular mechanism of K. paniculata to Cd stress at the gene transcription level.