Abstract：In order to effectively remove antibiotics and other organic pollutants in groundwater， activated sodium persulfate controlled-release materials （CRMs） was prepared with ordered mesoporous manganese oxide （O-MnOx） as active catalyst and sodium persulfate （Na2S2O8） as active oxidant， and was applied to the degradation and remediation of tetracycline in groundwater. The activation of sodium persulfate and the excellent degradation of tetracycline in water by O-MnOx were confirmed by two kinds of Fenton Catalytic reaction systems composed of ordered O-MnOx， H2O2 and Na2S2O8. The CRMs with O-MnOx and Na2S2O8 as active components can slowly release persulfate ions in groundwater. The higher of O-MnOx content， the slower of the release rate of persulfate. The Na2S2O8 addition enhanced the persulfate rate. O-MnOx can activate persulfate to dissolve sulfate radical， and then effectively degrade tetracycline in groundwater. For the groundwater with low concentration of tetracycline （≤10 mg·L-1）， the removal rate of tetracycline can reach more than 95% in one day. For high concentration of tetracycline （40 mg·L-1） in groundwater， O-MnOx in CRMs can activate persulfate for a long time. After 12 days， the removal rate of tetracycline in groundwater can reach more than 95%.