研究报告

  • 陈云增,李天奇,马建华,王琳,邹桂英,孙瑞玲.沙颍河流域典型癌病高发区居民硝酸盐和亚硝酸盐暴露及健康风险[J].环境科学学报,2018,38(1):363-371

  • 沙颍河流域典型癌病高发区居民硝酸盐和亚硝酸盐暴露及健康风险
  • Nitrate and nitrite exposure and health risk of local residents in a typical high cancer incidence area of Shaying River basin
  • 基金项目:国家自然科学基金(No.41371195);国家自然科学青年基金(No.41301336);教育部和河南省共建河南大学项目(No.SBGJ0907010)
  • 作者
  • 单位
  • 陈云增
  • 1. 河南大学环境与规划学院, 开封 475004;2. 河南大学环境与健康工程中心, 开封 475004
  • 李天奇
  • 河南大学环境与规划学院, 开封 475004
  • 马建华
  • 河南大学环境与规划学院, 开封 475004
  • 王琳
  • 河南大学环境与规划学院, 开封 475004
  • 邹桂英
  • 河南大学环境与规划学院, 开封 475004
  • 孙瑞玲
  • 河南大学环境与规划学院, 开封 475004
  • 摘要:为了解沙颍河流域典型癌病高发区居民硝酸盐和亚硝酸盐暴露状况和健康危害,通过采集饮水和蔬菜样品,调查和计算不同人群硝酸盐和亚硝酸盐暴露途径和暴露剂量,对居民硝酸盐和亚硝酸盐暴露的健康风险进行评估.结果表明,受到沙颍河污染的影响,饮水和蔬菜暴露剂量中,癌病高发村庄居民雨季硝酸盐暴露剂量的54.57%和亚硝酸盐暴露剂量的93.77%来自饮水.癌病高发村庄、镇区和其他村庄居民饮水及蔬菜的NO3--N年均暴露剂量分别达到2.052、1.457和1.028 mg·kg-1·d-1,均超过了0.836 mg·kg-1·d-1的日允许暴露剂量(ADI),癌病高发村庄居民雨季的NO3--N最高暴露剂量达到4.594 mg·kg-1·d-1,健康风险达到4.11×10-8 a-1,存在明显的硝酸盐暴露健康风险.除癌病高发村庄居民在旱季存在饮水亚硝酸盐直接暴露的健康风险外,研究区居民饮水和蔬菜亚硝酸盐直接暴露的健康风险总体上不明显.癌病高发村庄居民硝酸盐及亚硝酸盐暴露的健康风险明显高于区内其它居民.硝酸盐是癌病高发村庄居民健康风险的显著危害因子,较高的硝酸盐暴露剂量及其在体内的转化,可能成为癌病高发的因素之一.
  • Abstract:In order to understand nitrate and nitrite exposure and health damage of high cancer rate residents within Shaying River reaches, samples of dringking water and vegetables are collected to investigate the nitrate and nitrite exposure pathways of different people groups, as well as compute their exposure does and assess residents' health risks. The results showed that for the total exposure does intaked from drinking water and vegetables, 54.57% of nitrate exposure does and 93.77% nitrite exposures are from drinking water in the rain season due to being affected by Shaying River pollution. The annual average NO3--N exposure does from drinking water and vegetables of high cancer rate villagers, township residents and others reach 2.052、1.457 and 1.028 mg·kg-1·d-1 respectively, all exceed the acceptable daily intake(ADI). The high cancer rate villages reach the highest value of 4.594 mg·kg-1·d-1, which health risk is up to 4.11×10-8 a-1, indicating significant health risk of nitrate exposure. Generally, the residents' health risk of nitrite direct exposure from drinking water and vegetables is not obvious except high cancer rate villagers' in dry season. High cancer rate villagers' health risk of nitrate and nitrite direct exposure from drinking water and vegetables is far higher than others'. Nitrate is main damage factor for high cancer rate villagers' health risk. More high nitrate exposure does and it's in vivo transformation may be one of high cancer incidence factors.

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